Meanwhile, CXCL12 (HR: 0.730888940033441, 95% CI: 0.568482755798023–0.939691903078592, p-value: 0.0144802428352221), IGKC (HR: 0.82233697739277, 95% CI: 0.704030330155922–0.960524107303318, p-value: 0.0135803713395964), NOD2 (HR: 0.842773450385212, 95% CI: 0.719652065331376–0.986959008235654, p-value: 0.0337646407355474), VCAM1 (HR: 0.761232879031875, 95% CI: 0.6455778262167–0.897607496086219, p-value: 0.00117564947725508) and WNT5A (HR: 0.891231234461453, 95% CI: 0.800514277560811–0.992228540507633, p-value: 0.035517571353358) were protective factors of multiple myeloma. This evidence concerns the gene NOD2 and plasma cell myeloma.