As depicted by univariate cox regression analyses, among 31 common dysregulated immune-related mRNAs, AEN (HR: 1.35132218004432, 95% CI: 1.00336950593063–1.81993933788734, p-value: 0.0474670415899411), CD320 (HR: 1.2666572113788, 95% CI: 1.06872217896594–1.50125123508741, p-value: 0.0063988822159732), FABP5 (HR: 1.44824784649006, 95% CI: 1.25386429924306–1.67276620454803, p-value: 4.74125786831674e-07), and GPI (HR: 1.45171072863824, 95% CI: 1.06338050769041–1.98185317899107, p-value: 0.0189309122327046) were risk factors of multiple myeloma subjects in the GSE4204 dataset (Figure 3A). The gene discussed is GPI; the disease is AL amyloidosis.