Data showed that there were significant differences in the infiltration levels of B cells naïve (p < 0.001), B cells memory (p < 0.001), plasma cells (p < 0.001), T cells CD4 naïve (p = 0.028), resting memory CD4 T cells (p = 0.012), activated memory CD4 T cells (p = 0.016), Tregs (p < 0.001), resting NK cells (p = 0.007), M0 macrophages (p = 0.002), M1 macrophages (p < 0.001), M2 macrophages (p = 0.004), and neutrophils (p < 0.001) between multiple myeloma and normal bone marrow specimens (Figure 5). This evidence concerns the gene CD4 and plasma cell myeloma.