Among these core genes, some have been shown to play an important role in the pathogenesis of DN, C3 (52, 53), ALB (54–56), EGF (57), EGR1 (58–61), COL1A2 (62), FN1 (63, 64), CD44 (65, 66), FOS (67), PLG (68, 69), and DUSP1 (70). The gene discussed is EGF; the disease is liver dysplastic nodule.