Compared to healthy controls, the plasma levels of 10 cytokines of MPN patients, including BLC, Eotaxin-2, IL-7, IL-8, IL-13, IL-10, M-CSF, MIP-1β, sICAM-1, and TIMP-1, were remarkably elevated. This evidence concerns the gene CXCL13 and myeloproliferative neoplasm.