Providing further evidence that AML blasts have the ability to re-educate Mφs to a leukaemia supporting phenotype, Al-Matary et al. (2016), conducted pre-clinical studies with C1498-GFP, MLL-AF9, AML-ETO9a, and NUP98-HOXD13 syngeneic and transgenic AML mouse models. Here, HOXD13 is linked to acute myeloid leukemia.