CD47 and acute myeloid leukemia: Importantly, through analysis of microarray datasets from three independent adult AML patient cohorts (Valk et al., 2004; Bullinger et al., 2008; Metzeler et al., 2008), Majeti et al. (2009), demonstrated that high CD47 levels, were associated with a reduction in event-free survival and OS, as compared with AML patients exhibiting low expression of CD47.