Evidence for this potentially occurring in AML, comes from findings showing that most of these factors are elevated in BM plasma and/or blood plasma of AML patients especially IL-6, CCL2, with a corresponding increase in M2-like CD206+ monocytes and M2-like CD163+CD206+ Mφs (Table 1) occurring in the BM of AML patients (Mazur et al., 2007; Mussai et al., 2013; Sanchez-Correa et al., 2013; Su et al., 2013; Al-Matary et al., 2016). Here, IL6 is linked to acute myeloid leukemia.