RBCs therefore act as antigen sinks, and with this in mind, researchers have generated modified anti-CD47 antibodies, which exhibit reduced RBC binding and enhanced specific binding to AML cells, either via silencing of the Fc region (Pietsch et al., 2017) or augmentation through the incorporation of CD33-targeting light chain (Ponce et al., 2017). This evidence concerns the gene CD47 and acute myeloid leukemia.