Despite the observation from another study demonstrating that CD163+ and CD206+ macrophage populations were found to be infrequently enriched in AML BM samples, analysis at the single cell level will aid in identifying rare cell types that, when found alone or in association with other immune cell types, may exacerbate disease pathogenesis and therefore negatively impact patient prognosis (Guo et al., 2021). The gene discussed is MRC1; the disease is acute myeloid leukemia.