GFI1 and acute myeloid leukemia: Mechanistic insights into the leukaemia-driven AAM phenotype in the leukaemic mice, was provided through transcription factor growth factor independence 1 (Gfi1) expression, essential for myeloid differentiation, and shown to be involved in the ability of AML cells to preferentially polarise Mφs to an M2-like phenotype, at the expense of M1-like Mφs.