It has also been recently reported that the interplay between epigenetic and microRNA/transcriptional factors drive impaired M1-like Mφ polarisation in AML, in which the dynamic interplay between the newly discovered histone acetyltransferase monocytic leukaemia zinc finger (MOZ), and the general myeloid regulator microRNA miR-223 were inferred to be involved (Jiang et al., 2019). This evidence concerns the gene KAT6A and acute myeloid leukemia.