To extend these studies, here, we use several distinct models; two purely genetic ones to express KrasG12D for studying initiation combined with EHMT2 deletion (Pdx-Cre;LSL-KrasG12D;EHMT2fl/fl and P48Cre/+;LSL-KrasG12D;EHMT2fl/fl), an inducible Cre to investigate EHMT2 inactivation ex vivo (CAGGCre-ERTM;EHMT2fl/fl), as well as the model of pancreatitis-associated promotion (Guerra et al., 2007). This evidence concerns the gene PODXL and pancreatitis.