PRDM9 and pancreatitis: This result demonstrated that inactivation of this histone methyl transferase, in epithelial cells, leads to a change in the KrasG12D immune landscape in response to pancreatitis by significantly enriching the infiltrate with both cytotoxic and non-regulatory T cells and B cells, which are known to work in concert to mount more efficient antitumor responses (Wörmann et al., 2014).