TNF and pancreatitis: Overall, these data suggest that during the process of pancreatitis-enhanced carcinogenesis by KrasG12D, EHMT2 influences immunomodulatory processes, while reducing EMT, TNF-α signaling via NFκB, and KRAS signaling, which have well-documented effects on growth promotion (Thiery et al., 2009; Taniguchi and Karin, 2018; Waters and Der, 2018).