AR and posterior cortical atrophy: In PCa, activation of the PI3K/AKT pathway promotes the nuclear translocation of β-catenin, which triggers the expression of proliferation and EMT-related genes and specifically promotes tumor progression by transactivating androgen receptor and its downstream pathway (Sharma et al., 2002; Hennessy et al., 2005; Carnero, 2010; Noorolyai et al., 2019).