Several studies show that it promotes PCa initiation and progression by transactivating the androgen receptor (Deocampo et al., 2004; Hong et al., 2005; Link et al., 2005), but there are also reports that some subunits function as tumor suppressors (Hansen et al., 2011; Lee and Roberts, 2013; Prensner et al., 2013). This evidence concerns the gene AR and posterior cortical atrophy.