RB1 and posterior cortical atrophy: Multiple mutations in several key epigenetic factors, including Rb1 and BRCA, drive the progression of PCa to aggressive phenotype at terminal stage, characterized by limited survival, revealing an important role of epigenetic dysregulation on PCa progression (Crea et al., 2011; Liu, 2016; Chan et al., 2018; Sheahan and Ellis, 2018; Oh et al., 2019; Wu et al., 2019; Ge et al., 2020; Liang et al., 2020).