SMARCC1 and posterior cortical atrophy: Consistent with previous reports, we found that SMARCC1 knockdown accelerated cell cycle transition and induced a hyper-proliferative phenotype in PCa cell lines by upregulating G1/S-specific protein cyclin D1/E1 but downregulating cyclin-dependent kinase inhibitors p21 and p27, implying that SMARCC1 may be a potential druggable target for cell cycle checkpoint pathway in PCa.