To validate the potential impact of SMARCC1 depletion on PCa cell proliferation in vivo, PC-3/sh-SMARCC1 cells and PC-3/sh-Ctrl as well as 22Rv1/sh-SMARCC1 cells and 22Rv1/sh-Ctrl cells were injected subcutaneously in nude mice. Here, SMARCC1 is linked to posterior cortical atrophy.