The downregulation of PUFA-ePL is associated with tumor cell resistance to ferroptosis peroxisomal biogenesis factor 3 (PEX3), peroxisomal biogenesis factor 10 (PEX10), peroxisomal biogenesis genes, and alkylglycerone phosphate synthase (AGPS), and fatty acyl-CoA reductase 1 (FAR1) encoding peroxisomal enzymes is considered to contribute to these effects. This evidence concerns the gene PEX10 and neoplasm.