Their sometimes opposing roles in lung cancer progression are indicated by studies showing that EVs modulated integrin trafficking in fibroblasts and enhanced tumor cell migration in NSCLC by carrying podocalyxin (Novo et al., 2018), and they prevented metastatic angiogenesis in LUAD by transporting miR-192 (Valencia et al., 2014). The gene discussed is PODXL; the disease is neoplasm.