AR and chronic obstructive pulmonary disease: Interestingly, we found Cytoskeleton remodeling (Keratin filaments) and Statin action on the PI3K/Akt pathway in COPD were enriched in pathway maps, and Cell adhesion (Integrin-mediated cell-matrix adhesion) and Signal transduction (Androgen receptor signaling cross-talk) were enriched in process networks (Figure 7C).