Previously, three rare missense mutations (S26L-rs561648554, S254A-rs182740317, and S285C-rs762500782) in Sestrin2 (SESN2), which co-segregates with CHD phenotype, were identified from exome sequencing of three sporadic, non-syndromic CHD patient-parent trios in high-altitude areas (Supplementary Table 1). This evidence concerns the gene SESN2 and coronary artery disorder.