SESN2 and coronary artery disorder: Our study provides evidence that rs492554 is associated with CHD susceptibility in high-altitude populations and also has an eQTL effect on the downstream hypoxia response gene SESN2. SESN2 protects against oxidative stress and cell apoptosis and maintains cell viability and proliferation in the hypoxia-mimetic cobalt chloride-induced H9c2 cell model.