SESN2 and coronary artery disorder: As long-term hypoxic exposure is considered to be one of the causes of heart development defects in high-altitude populations, and SESN2 seems to be a genetic factor representing a potential link between hypoxia and CHD, we also examined whether SESN2 is involved in regulating the phenotype of cardiomyocytes under hypoxic conditions, by overexpressing or knocking down Sesn2 in embryonic rat-heart-derived H9c2 cells treated with or without CoCl2.