Recently, Osborne et al. (2016); Bringman-Rodenbarger et al. (2018), and Kumar and Lombard (2018) showed that SIRT5 plays an important role in cancer models, including tumor suppression and tumor metabolism (Osborne et al., 2016; Bringman-Rodenbarger et al., 2018; Kumar and Lombard, 2018). This evidence concerns the gene SIRT5 and neoplasm.