T cell synapse defects appear to be more severe in WIP-deficiency as they are in WASP-deficiency (Calvez et al., 2011; Pfajfer et al., 2017), although these 2 deficiencies have not formally been compared side by side with similar models and stimulations. This evidence concerns the gene WIPF1 and hyperinsulinemic hypoglycemia, familial, 4.