BTK and B-cell chronic lymphocytic leukemia: Specifically, BTK is a tissue specific target for inhibition in various B-cell lymphomas including diffuse large B-cell lymphoma (DLBCL) and chronic lymphocytic leukemia (CLL) (Davis et al., 2010; Herishanu et al., 2011); proliferation of these lymphomas strictly depends on the activation of the BTK signaling cascade.