Parental high-fat diet increased offspring obesity and type 2 diabetes mellitus risks through the regulation of SLC28A2 (solute carrier family 38 member 2) expression (Krout et al., 2018; Claycombe-Larson et al., 2020), which indicated that lncRNA-SLC28A2 may be associated with chicken lipid synthesis. The gene discussed is SLC28A2; the disease is obesity due to melanocortin 4 receptor deficiency.