BC cell-derived exosomes can transfer SNHG16 to γδT1 cells, and CD73 + γδT1 cells are the main regulatory T cells in BC, which play an immunomodulatory role in tumor microenvironment (Salmena et al., 2011; Ni et al., 2020) have proposed a competing endogenous RNA (ceRNA) mechanism in which lncRNA, microRNA (miRNA), and mRNA can achieve crosstalk among each other through forming a regulatory network. This evidence concerns the gene NT5E and breast cancer.