In the whole COVID-19 cohort the distribution of the genotypes of IFNL3, IFNL4, MERTK and PNPLA was in accord to the Hardy-Weinberg equilibrium, while the allelic distribution of the TLL-1 variant rs17047200 (A > T) (Table 3) showed a statistically significant divergence from Hardy Weinberg since the number of TT homozygotes observed was higher (11) than expected (6.3). The gene discussed is IFNL3; the disease is COVID-19.