Results of immunohistochemistry showed in Figure 1F was similar to that of Elisa assay that Ghrelin and Ghrelin receptor expression of prostate tend to be up-regulated in HFD fed mice (Control and BPH) while BPH animals showed relative higher Ghrelin and Ghrelin receptor expression in prostate tissue. The gene discussed is GHSR; the disease is benign prostatic hyperplasia.