Moreover, YIL-781 attenuates prostate enlargement in HFP and TP BPH mice, WP1066 blocks ghrelin-induced cell proliferation and apoptosis inhibition, increased Bcl2 and decreased BAX expression also strengthens the evidence that Ghrelin promotes cell proliferations while inhibits apoptosis in the prostate gland through Jak2/STAT3 pathway. Here, GHRL is linked to benign prostatic hyperplasia.