First, while GAPDH is not significantly differentially expressed in UM compared with normal controls and is commonly used as a control for gene expression studies, GAPDHS is specifically expressed in melanoma and in sperm and is expressed at low levels or not expressed in other tumors according to the GEPIA database, and it regulates tumorigenesis by modulating glycolysis efficiently to control glycolytic flux, which suggests that GAPDHS may play a more important role than GAPDH and that inhibitors targeting GAPDHS may be an approach with therapeutic benefit in melanoma. This evidence concerns the gene GAPDHS and melanoma.