The nuclear factor erythroid–related factor 2 (Nrf2)/kelch-like erythroid cell–derived protein 1 (Keap1) pathway encompasses a central cellular defense mechanism that maintains redox homeostasis, but is disrupted in T2DM (Kensler et al., 2007; Soares et al., 2016). This evidence concerns the gene KEAP1 and type 2 diabetes mellitus.