Incorporation of FGF-2 within the scaffold was obtain by soaking the scaffold in FGF-2 solution, while its release enhanced cell proliferation rate, tissue morphology, collagen fibril assembly, and blood vessel formation, and demonstrated great potential for major cutaneous defects, such as repairing large-area skin damage and chronic skin wounds due to lower granulation (Xiong et al., 2017). Here, FGF2 is linked to skin wound.