All 59 YST cases were negative for OCT4, but strong positive for SALL4. More than 90% of the tumor area in 54 cases and 70% to 85% tumor area in 5 YST cases was noted making SALL 4 a novel and sensitive marker in YST. 66% cases showed focal PLAP staining. The gene discussed is SALL4; the disease is neoplasm.