The decrease of proinflammatory cytokines could be associated with a reduction of infection and absence of hyphae, once the marked release of IL-6 occurs due to the exposition of hyphal fragments of A. fumigatus (Øya et al., 2019) TNF plays an important role in host immune defense against invasive fungal infections (Filler et al., 2005). This evidence concerns the gene TNF and fungal infectious disease.