NFE2L2 and cancer: Nuclear factor-erythroid 2-related factor 2 (Nrf2) has a dual-role as this can protect the cells from transforming into cancer cells (anticarcinogenic property) and can promote the survival of cancer cells under detrimental conditions (procarcinogenic property) (Lau et al., 2008; Menegon et al., 2016; Son et al., 2019b).