E2 of the AOM/DSS-treated group with “Sex and KO” criteria comprised the gut microbiota of four male WT AOM/DSS-treated, four female WT AOM/DSS-treated, one male Nrf2 KO AOM/DSS-treated, and five female Nrf2 KO AOM/DSS-treated mice. The gene discussed is NFE2L2; the disease is infectious otitis media.