The analysis of gut bacteria with an abundance of more than 1% revealed two sex-specific bacteria (A. muciniphila and L. murinus), four CRC-specific bacteria (A. muciniphila, B. vulgatus, L. murinus, and M. intestinale), and three Nrf2 KO-specific bacteria (B. vulgatus, L. murinus, and M. intestinale). The gene discussed is NFE2L2; the disease is colorectal carcinoma.