The Nrf2 target genes, such as heme oxygenase-1 (HO-1) and NAD(P)H-quinone oxidoreductase-1 (NQO1) are reported to mediate chemotherapy resistance in several cancers, including gastric (Yang et al., 2011) and colon cancers (Schlager and Powis, 1990). This evidence concerns the gene NFE2L2 and colonic neoplasm.