Our study demonstrated CRC patients with high-risk scores or in the high-risk group harboring obvious immune-suppressive features: there was a higher infiltration of M0 Macrophages, and M2 Macrophages and lower infiltration of CD8+ T cells and CD4+ memory T cells in the high-risk group, indicating ferroptosis was involved in tumor immune microenvironment and a stronger immunosuppressive effect contributed to poor survival of CRC patients in the high-risk group. This evidence concerns the gene CD4 and neoplasm.