We explored four multidimensional cancer genomics data sets using cBioPortal applications, querying HSPG-related genes: HSPG2, SDC1, SDC2, SDC3, SDC4, GPC1, GPC2, GPC3, GPC4, GPC5, GPC6, SULF1, SULF2, HS6ST1, NDST1, NDST2, NDST3, NDST4 and HPSE. The gene discussed is SDC3; the disease is cancer.