CD274 and neoplasm: Figure 3 (right) shows Kaplan-Meier survival curves for cohorts of tumor-bearing, anti-PD-L1-treated mice. The survival of tumor-bearing mice whose brains were not irradiated (n=15; dashed line) is significantly greater than for mice whose brains were irradiated six weeks prior to tumor implantation (n=14; solid line). The ~50% survival of anti-PD-L1-treated, non-irradiated mice is consistent with previously published studies of ICI-treated mice (21, 23–25).