In this study, we found that CD8 T-cell infiltration and IFN-γ production were upregulated by 15 Gy radiation in both the irradiated and non-irradiated tumors with high immunogenicity, which was accompanied by the downregulation of suppressive immune cells (MDSCs and TAMs) at the tumor sites (Figure 3 and Supplementary Figure 3). This evidence concerns the gene IFNG and neoplasm.