In our study, by reviewing the clinicopathological features, genetic mutations, tumor microenvironment (TME), and survival of 31 IMA patients, we aimed to clarify PD-L1 expression and tumor-infiltrating lymphocytes (TILs) in IMA, the correlation between these factors and patient’s survival, and the potential of targeted therapy and immunotherapy in IMA patients. Here, CD274 is linked to neoplasm.