SPNS2 and colorectal carcinoma: Methylation level of CpG loci in SPNS2 gene’s promoter (Figures 4G, H) and TSS upstream 1kb (Figure 4I) negatively correlated with SPNS2 expression significantly in CRC cell lines (r = -0.6418, p < 0.0001; r = -0.5979, p < 0.0001; r = -0.7215, p < 0.0001; respectively).