To further confirm the role of AKT signaling in SPNS2‐regulated migration and invasion in CRC, we performed transwell assays in SW480 si-SPNS2 and HCT116 OE-SPNS2 cells after treatments with MK2206 (an AKT inhibitor) or SC79 (an AKT activator). Here, SPNS2 is linked to colorectal carcinoma.