SPNS2 expression was markedly lower in ten kinds of tumor compared to the adjacent noncancerous samples, such as BRCA (Breast invasive carcinoma), LIHC (Liver hepatocellular carcinoma), LUAD (Lung adenocarcinoma) and LUSC (Lung squamous cell carcinoma) (Figure 1A). Here, SPNS2 is linked to squamous cell lung carcinoma.