SPNS2 and colorectal carcinoma: GSEA analysis also revealed that SPNS2 expression was negatively associated with the functional gene sets of “HALLMARK EPITHELIAL MESENCHYMAL TRANSITION” (NES = -1.70, FDR q-value = 0.002, Figure 6A) in CCLE CRC cell lines, in line with the above findings that SPNS2 expression levels were lower in advanced N/M stages and liver metastasis (Figures 2B, C, H).