During the metabolic adaptation of cancer cells, the dual role of MCT1 and MCT4 in maintaining the glycolytic phenotype by, on the one hand, facilitating lactate efflux and, on the other hand, contributing to the preservation of intracellular pH through co-transport with a proton determines the increased expression of these isoforms in tumor cells (16), as well as that of their chaperone CD147 (17). The gene discussed is BSG; the disease is cancer.