Among other proteins, the authors analyzed the expression of proteins involved in the metabolic reprogramming of cancer cells, such as HIF-1α, GLUT1, phosphorylated mTOR, phosphorylated S6, AMPKα1 and phosphorylated Akt, and identified a higher expression of proteins associated with the hypoxic tumor microenvironment, such as GLUT1 and HIF-1α, in squamous cell carcinomas. This evidence concerns the gene HIF1A and squamous cell carcinoma.