Several proteins play an important role in the metabolic reprogramming of tumor cells (13), such as glucose transporter 1 (GLUT1), a transmembrane protein that facilitates glucose influx (14, 15), monocarboxylate transporters (MCTs), particularly isoforms 1 and 4, because of their function in lactate efflux (16) in close association with their chaperone CD147 (17), and carbonic anhydrase 9 (CAIX), a pH regulator contributing to preservation of intracellular pH (18). This evidence concerns the gene CA9 and neoplasm.