CASK and hepatocellular carcinoma: Quite interestingly, we found that HCC cell lines with lower levels of CASK were more sensitive to sorafenib treatment (The IC50 to sorafenib of SMMC-7721 cell was 9.97 μM, SK-Hep-1 cell was 15 μM and SMMC-7721-sora cell was 22.2 μM).