CRT0066101 can inhibit cell proliferation, induce apoptosis, reduce PKD1/2 activity induced by neurotensin, reduce neurotensin-induced PKD-mediated Hsp27 phosphorylation, inhibit NF- κB activation, and block NF-κB-dependent proliferation and survival in pancreatic cancer. Here, PKD1 is linked to familial pancreatic carcinoma.