In White women, an increased risk of ER+ breast cancer was observed for COX2-rs689470 (OR: 2.60, 95% CI: 1.46–4.63) in the dominant model, whereas a reduced risk was observed for ALOX5-rs7099874 (OR: 0.66, 95% CI: 0.51–0.85) in a dominant model. Here, ALOX5 is linked to breast cancer.