LINC00968 is under expressed in LUAD and inhibits tumor cell growth through the linc00968/miR-9-5p/CPEB3 (56) and miR-21-5p/SMAD7 (57) axes.LINC00628 is a tumor suppressor gene in multiple tumors, including gastric cancer (58), breast cancer (59), osteosarcoma (60) and hepatocellular carcinoma(HCC) (61). This evidence concerns the gene SMAD7 and hepatocellular carcinoma.