For example, TP53-mutated lung adenocarcinoma and breast cancer exhibit enhanced PD-L1 expression and immune cell infiltration, which indicate a good response to ICIs, while in colon adenocarcinoma, head and neck squamous cell carcinoma and stomach adenocarcinoma, TP53 mutation showed the opposite effect (38). This evidence concerns the gene TP53 and colon adenocarcinoma.