For example, TP53-mutated lung adenocarcinoma and breast cancer exhibit enhanced PD-L1 expression and immune cell infiltration, which indicate a good response to ICIs, while in colon adenocarcinoma, head and neck squamous cell carcinoma and stomach adenocarcinoma, TP53 mutation showed the opposite effect (38). The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.