And we verified the five genes in TCGA-LUAD, and the results were consistent with the original results, in which the expression of KRT6A and KIF20A was higher in cancer tissues than that in paracancerous tissues, while the expression of KLF4, LIFR and RGS13 is on the contrary (Supplementary Figures 1A–E). The gene discussed is KRT6A; the disease is cancer.