The pivotal role of BAP1 in mesothelioma is confirmed also at the somatic level, since 60% of cases present a second hit (120), even if the percentage could be even higher since studies performed so far have used next generation sequencing (NGS) approaches that lacked the identification of large deletions, while assessment from different platforms, like IHC and multiplex ligation–dependent probe amplification (MLPA) have increased detection perfomances (116). This evidence concerns the gene BAP1 and mesothelioma.