Interestingly, inter- and intra-chromosomal rearrangements affected genes like CDKN2A, one of the most frequently mutated in mesothelioma and KDM6A, a gene that has been associated with sensitivity to enhancer of zeste homolog 2 (EZH2) inhibitors, like tazemetostat (151, 153). The gene discussed is EZH2; the disease is mesothelioma.