In general, ccRCC could be properly differentiated from normal tissues using SLC22A12 expression levels with an AUC of 0.7258 (p < 0.0001; Figure 4A) in the TCGA-KIRC cohort and 0.8926( p< 0.0001; Figure S1D) in the ICGC-RECA cohort. Here, SLC22A12 is linked to nonpapillary renal cell carcinoma.