To explore the potential downstream pathways of FSCN1 by selecting genes correlated only with FSCN1 expression in either PIK3CA-wild-type or PIK3CA-altered patients (|r| >0.4) for the GO analysis (Supplementary Figure S2A), we found that the same signaling pathway (“protein targeting”) was enriched according to the gene function enrichment analysis in PIK3CA-altered patients in both cancer types (Supplementary Figure S2B). This evidence concerns the gene FSCN1 and cancer.