We hypothesize that piR-hsa-211106 might work in two ways: 1) piR-hsa-211106 in nuclear triggers PC gene methylation through DNA methylation pathways, thereby restricting the transcription and translation of PC gene; 2) piR-hsa-211106 in the cytoplasm combines with PC, hindering its normal function, thereby suppressing tumor growth. The gene discussed is PIR; the disease is pachyonychia congenita.