Notably, a high prevalence of KDM5C and BAP1 alterations was identified in both the primary tumor and VTT tissues from ccRCC patients with VTT in our cohort (KDM5C: 21.74, 24.00, 4.00, and 7.00%; BAP1 30.43, 24.00, 4.00, and 10.00% for V, VP, NP, and TCGA, respectively). This evidence concerns the gene BAP1 and neoplasm.