Compared with benign lesions, due to tumor angiogenesis regulation factor(such as VEGF and angiogenin) imbalances, highly disordered vascular tissues, such as altered diameter expansion, radial penetration from the edge of the tumor, excessive branch shunts, abnormal structure and function at the tumor edge, radial penetration and other structural and functional abnormalities (32–35). The gene discussed is VEGFA; the disease is neoplasm.