TARBP2 and cancer: Examining RNA-Seq profiles in the oe/sh-TARBP2 cell lines, several cancer-related pathways, such as the HIF-1 signaling pathway which played a pivotal role in HCC progression (43), were found to be significantly enriched among the differential genes in the cell lines, suggesting a systematic change in transcriptional profiles of various cancer-related genes after either overexpression or knockdown of TARBP2. Several functional genes involving the HIF-1 pathway were further evaluated in HCC cell lines and clinical specimens.