TNF and cancer: The KEGG and GO analysis revealed enriched pathways and biological processes relevant to cancer pathobiology, including such pathways as “Wnt signaling pathway”, “HIF-1 signaling pathway”, and “Adrenergic signaling in cardiomyocytes”; as well as such biological processes as “Negative regulation of tumor necrosis factor production”, “Axon guidance”, and “Cellular response to interferon-gamma” (Figure 4C).