confirmed that circUHRF1 inhibits the activation of natural killer cells and the release of cytokines (IFN-γ and TNF-α) through sponge miR-449c-5p in hepatocellular carcinoma, which induced resistance to anti-PD-1 therapy in patients with hepatocellular carcinoma (30). The gene discussed is IFNG; the disease is hepatocellular carcinoma.