Exosomes circFMN2 upregulated the expression of seven target genes (CD44, G protein subunit gamma 7 [GNG7], RB transcriptional corepressor 1 [RB1], collagen type I alpha 2 chain [COL1A2], phospholipase C beta 1 [PLCB1], solute carrier family 17 member 7 [SLC17A7], telomerase reverse transcriptase [TERT]) by binding miR-1182, thereby promoting the occurrence and development of colorectal cancer (Table 2). This evidence concerns the gene RB1 and colorectal cancer.