Induction of OAS1 to increase the anti-cancer effects of interferon gamma, suppression of CTSH to hinder formation of focal adhesions, expression inhibition of ATF5 gene to make cancer cells sensitive to anchorage-dependent death signals, and induction of LGALS4 gene (supported by survival analysis) to recover cell-cell junctions would be the combination of genetic targets that prevent EMT and cell migration. The gene discussed is CTSH; the disease is cancer.