MPN: myeloproliferative neoplasm; JAK: Janus kinase; STAT: signal transducer and activator of transcription proteins; CSF3R: colony-stimulating factor 3 receptor; ASXL1: ASXL transcriptional regulator 1; CNL: chronic neutrophilic leukemia; SETBP1: SET binding protein 1. The gene discussed is ASXL1; the disease is myeloproliferative disorder.