It can be implicated from the National Kidney Foundation Kidney Disease Outcomes Quality Initiative classification of chronic kidney disease (CKD) as glomerular filtration rate (GFR) less than 15 ml/min/1.73 m2 of body surface area and severely increased albuminuria (>300 mg/g of albumin creatinine ratio or >300 mg of albumin excretion rate in 24 hours) or those requiring renal replacement therapy irrespective of GFR/albuminuria. The gene discussed is ALB; the disease is kidney disorder.