AMI - acute myocardial infarction; CVD - cardiovascular disease; DM - diabetes mellitus; DPA - dorsalis pedis artery; HPR - high-on treatment platelet reactivity; hs-CRP - high sensitivity C-reactive protein; HTN - hypertension; MS - metabolic syndrome; MPA - medial plantar artery; NT-pro-BNP - N terminal-pro-B-type natriuretic peptide; NSTEMI - non-ST segment elevation myocardial infarction; PCI - percutaneous intervention; PFA - profunda femoris artery; PTA - posterior tibial artery; QOL - quality of life. The gene discussed is NPPB; the disease is diabetes mellitus.