AKT1 and neoplasm: Phosphorylated Akt activates various protein kinases and mechanistic targets of rapamycin (mTOR) and is an important downstream effector in the phosphatidylinositol 3-kinase (PI3K) and Akt signal pathways, by which it regulates tumor cell proliferation, angiogenesis, and immunity (Ma et al., 2020; Rho et al., 2020).