PPIG and gastrointestinal disease: Background: Zuotai (mainly β-HgS)-containing 70 Wei-Zhen-Zhu-Wan (70W,Rannasangpei) is a famous Tibetan medicine for treating cardiovascular and gastrointestinal diseases.  We have shown that 70W protected against CCl4 hepatotoxicity.  CCl4 is metabolized via cytochrome P450 (CYP) to produce reactive metabolites.